Not since the Qatar Open at the start of 2017 have the pair met on court, but Murray’s impressive run in Spain has earned him a clash against the world number one.
The 34-year-old beat Dominic Thiem, himself looking to find his way back to form after injury problems, in the opening round before backing that up with a hugely impressive win over Denis Shapovalov.
Murray managed just eight games against the Canadian when the two played at Wimbledon last summer.
Now the British star faces the sternest of tests, though Djokovic has had a frustrating year on and off the court so far. He is still looking for his first title of 2022, having recently lost on home soil to Andrey Rublev in the final of the Serbia Open.
Murray has looked comfortable on the Madrid clay so far, but he knows he will have to be at his very best if he is to get the better of his long-time rival.
“In theory, I should have no chance in the match,” Murray said.
“He’s obviously No1 in the world and I’m playing with a metal hip so I shouldn’t have a chance in the match. It’s a great opportunity for me to see where my game’s at and to play against him.”
He added: “I didn’t know if I ever would get that chance so I’ll enjoy it, I’ll have a fantastic attitude in the match, give it my best and see where I’m at.”
Date, venue and UK start time
The round of 16 match between Andy Murray and Novak Djokovic will take place on Thursday, May 5 2022.
The match is scheduled to get underway at approximately 11am BST.
Dusan Lajovic or the winner of Hubert Hurkacz vs Alejandro Davidovich Fokina await in the quarter-finals.
How to watch Andy Murray vs Novak Djokovic
TV channel: The match will be broadcast live on the Amazon Prime streaming service.
Live stream: Amazon Prime subscribers will be able to watch the match either on their website or through the app.
Andy Murray vs Novak Djokovic head-to-head record
There is very little the pair don’t know about each other’s games. Murray and Djokovic have met in the final of every Grand Slam and played each other 36 times, but this will be the first meeting since 2017.
Djokovic has won five of the six matches played on clay, including the Madrid Open final in 2016.
Murray wins: 11
Djokovic wins: 25