On each of the two previous occasions the sides have met at this stage of the competition, the team from Merseyside claimed victory in both legs and went on to lift the trophy.
In 1978, Emlyn Hughes and Jimmy Case struck in Lisbon to help set up the Reds’ eventual victory over Brugge at Wembley. Four years later, a 5-1 aggregate victory secured passage towards their famous triumph in Rome.
Jurgen Klopp has already lifted the Champions League with Liverpool and is still chasing an unprecedented quadruple this term after downing Inter Milan in the last round, before a routine domestic victory over Watford at the weekend.
They also won the Carabao Cup in February and meet Manchester City in the FA Cup semi-finals at Wembley soon.
Benfica, meanwhile, shocked Ajax in the last-16 yet sit third in the Primeira Liga and are well off the pace in that title fight.
Date, kick-off time and venue
Benfica vs Liverpool is scheduled for an 8pm BST kick-off tonight, Tuesday April 5, 2022.
Lisbon’s Estadio da Luz will host the match.
Where to watch Benfica vs Liverpool
TV channel: Tonight’s match will be televised live on BT Sport 3, with coverage beginning at 7.15pm.
Live stream: BT Sport subscribers will also be able to watch the game online via the BT Sport website or app.
Live blog: You can follow all the action via Standard Sport’s live match blog.
Benfica vs Liverpool team news
Haris Seferovic returned to the Benfica squad for Friday’s defeat at Braga although Adel Taarabt is a doubt. Rodrigo Pinho and Lucas Verissimo are out.
Klopp was able to leave Trent Alexander-Arnold on the Liverpool bench on Saturday following his recovery from a hamstring issue. Sadio Mane and Luis Diaz were also saved from the lineup following international duties.
All three could return in Lisbon with Naby Keita back in training from a knee issue. Curtis Jones and Joel Matip have also shaken off knocks picked up against Watford.
Benfica vs Liverpool prediction
The Reds managed to get the job done in the away leg back in the last-16, despite not playing particularly well at Inter Milan. On this occasion, they face a Benfica team more than happy to cause an upset.
Still, betting against Liverpool these days does not feel like the smartest of endeavours.
2-1 away win.
Head to head (h2h) history and results
Benfica wins: 4
Liverpool wins: 6