Kante missed last weekend’s 1-0 defeat at Everton and is not ready to return, while Jorginho was substituted with an injury at half-time at Goodison Park.
“For N’Golo the match comes a little too early,” confirmed Chelsea manager Thomas Tuchel on Friday. “Jorgi is out as well, so these two we are missing.
“And Callum [Hudson-Odoi] and Ben Chilwell are still out. The rest are available.”
Mateo Kovacic is set to replace Jorginho in midfield alongside Loftus-Cheek, while Hakim Ziyech is pushing to start after impressing off the bench against Everton.
Romelu Lukaku was left on the bench at Goodison Park when Chelsea were chasing an equaliser.
Tuchel said: “He has trained very well and maybe he starts tomorrow, let’s see.”
Asked what Lukaku needs to do change his fortunes at Chelsea, Tuchel added: “I don’t know what needs to happen. He needs to happen, everyone needs to happen. This is the life of a footballer at this level. It needs to happen, he needs to happen and we have to support him.”
Predicted Chelsea XI (3-4-3): Mendy; Azpilicueta, Silva, Rudiger; James, Kovacic, Loftus-Cheek, Alonso; Ziyech, Lukaku, Mount.