The Etihad Stadium hosts the first leg, which pits the champions of England against the champions of Spain – the latter having already downed one Manchester club in this season’s competition.
Billed by some as a clash of styles between Pep Guardiola and Diego Simeone, the City boss has moved to quieten the “stupid debate” over how popular Atletico’s tactics are.
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Both teams are on good form heading into this one and claimed domestic victories on the weekend to set up one of the most intriguing ties of the round.
With kick-off at 8pm BST, here are all the details for tuning in…
Where to watch Manchester City vs Atletico Madrid
TV channel: The match will be televised on BT Sport 2 and Ultimate, with coverage beginning at 7pm.
Live stream: BT Sport subscribers will be able to watch the match online via the BT Sport website or app.
Live blog: You can follow all the action via Standard Sport’s live blog.