United crashed out of the FA Cup on penalties against Championship side Middlesbrough last weekend then dropped out of the top four on Tuesday after being to a 1-1 draw at a Burnley side bottom of the Premier League.
They face another difficult afternoon against a Southampton side fresh from a brilliant 3-2 win at Tottenham on Wednesday night and full of confidence under Ralph Hasenhuttl.
Where to watch Man United vs Southampton
TV channel: The game will be broadcast on BT Sport 1. Coverage begins at 11.30pm GMT.
Live stream: BT Sport subscribers will be able to watch the game through either their website or the BT Sport App.
Live blog: You will be able to follow all the action with Standard Sport’s LIVE blog.