The Selecao were held to a 1-1 draw with Spain in their opening game, while the Swiss fell to defeat against the Czech Republic.
The major talking point for Portugal was the fact Cristiano Ronaldo started on the bench, meaning he will surely be handed the chance to add to his already record-breaking international goal haul from the start this time around.
So poor on the road, it looks a very difficult ask for Switzerland, although their impressive showing at the Euros did hint a team coming of age.
Here’s how to keep across all of the action.
Where to watch Portugal vs Switzerland
TV channel: The match will be televised on Premier Sports 2, with coverage beginning at 19.30pm BST before a 19.45pm kick-off. A monthly subscription costs from £9.99 in the UK.
Live stream: Premier Sports subscribers will be able to watch the game online via the Premier Player on mobile and tablet devices.