The Belgian underwent ankle surgery last week to rule him out of the entire quarter-final tie against his old team, which begins at Stamford Bridge on Wednesday.
A back issue means Spanish midfielder Isco is unavailable while striker Jovic picked up an ankle injury during the international period, leading to the trio being left out of Madrid’s matchday squad.
Real have no other injury worries, allowing Carlo Ancelotti to select a first-choice line-up.
In fact, it is the coach himself who is the biggest doubt while he continues to wait for a negative Covid test.
Last week, the Italian was ruled out of the win at Celta Vigo due to the virus and he reportedly remains under isolation orders.
Predicted Real Madrid XI: Courtois; Carvajal, Militao, Alaba, Mendy; Modric, Casemiro, Kroos; Asensio, Benzema, Vinicius.