The 26-year-old defender has featured 25 times this season under Mark Robinson in League One and scored three goals in the early stage of the campaign before suffering sprains to his ankle, ACL and posterolateral corner in training in mid-October.
Nightingale, born in Wandsworth, has made more than 150 appearances for the South Londoners since making his first-team debut in 2014.
“I am delighted to have signed – everyone knows how much this club means to me,” said Nightingale, who has been at the club for 18 years. “It’s important for myself to tie myself down, and now all I want to do is focus on keeping this club up in the league.
“I have got to go and show what I am about really – I have got to prove that I deserve this and go and perform on the pitch.
“I know that we’re in a tough position at the minute, but every single bit of my focus is on keeping us up.
“It’s a club that is on the up. It’s not going to feel like it at the minute, but I do believe that this club has so much potential, and we just [need to] fine-tune the important bits at the minute that we’re not quite getting right.”
Wimbledon find themselves just a point above the League One relegation zone and without a win in 18 games in all competitions.
“Although things might not seem like it at present, there are so many things that we are getting right behind the scenes that, when we do get the other bits right on the pitch, then I do believe this club will flourish,” added Nightingale.
“We are working hard, and fair enough, we have got to work harder, be better and improve. We completely understand that, and that’s what we’re striving to do.”
PICTURE: KEITH GILLARD